Basal ganglia-premotor dysfunction during movement imagination in writer's cramp.
Identifieur interne : 000E74 ( Main/Exploration ); précédent : 000E73; suivant : 000E75Basal ganglia-premotor dysfunction during movement imagination in writer's cramp.
Auteurs : Florian Castrop [Allemagne] ; Christian Dresel ; Andreas Hennenlotter ; Claus Zimmer ; Bernhard HaslingerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Basal Ganglia (blood supply), Basal Ganglia (physiopathology), Dystonic Disorders (pathology), Dystonic Disorders (physiopathology), Female, Functional Laterality (physiology), Humans, Image Processing, Computer-Assisted, Imagination (physiology), Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex (blood supply), Motor Cortex (physiopathology), Movement (physiology), Neural Pathways (blood supply), Neural Pathways (physiopathology), Oxygen (blood), Photic Stimulation, Severity of Illness Index.
- MESH :
- chemical , blood : Oxygen.
- blood supply : Basal Ganglia, Motor Cortex, Neural Pathways.
- pathology : Dystonic Disorders.
- physiology : Functional Laterality, Imagination, Movement.
- physiopathology : Basal Ganglia, Dystonic Disorders, Motor Cortex, Neural Pathways.
- Adult, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Photic Stimulation, Severity of Illness Index.
Abstract
The pathophysiology of idiopathic focal hand dystonia (writer's cramp) is characterized by deficient inhibitory basal ganglia function and altered cortical sensorimotor processing. To explore if this is already a primary finding in dystonia for internal movement simulation independent of dystonic motor output or abnormal sensory input, we investigated the neural correlates of movement imagination and observation in patients with writer's cramp. Event-related fMRI was applied during kinesthetic motor imagery of drawing simple geometric figures (imagination task) and passively observing videos of hands drawing identical figures (observation task). Compared with healthy controls, patients with writer's cramp showed deficient activation of the left primary sensorimotor cortex, mesial and left dorsal premotor cortex, bilateral putamen, and bilateral thalamus during motor imagery. No significant signal differences between both groups were found during the observation task. We conclude that internal movement simulation and planning as tested during imagination of hand movements appear to be dysfunctional in patients with writer's cramp, whereas visual signal processing and observation-induced activation are unaffected. Deficient basal ganglia-premotor activation could be a correlate of impaired basal ganglia inhibition and focusing during the selection of motor programs in dystonia. This finding seems to be an intrinsic deficit, as it is found during motor imagery in the absence of dystonic symptoms.
DOI: 10.1002/mds.24944
PubMed: 22328061
Affiliations:
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last="Dresel">Christian Dresel</name></author><author><name sortKey="Hennenlotter, Andreas" sort="Hennenlotter, Andreas" uniqKey="Hennenlotter A" first="Andreas" last="Hennenlotter">Andreas Hennenlotter</name></author><author><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name></author><author><name sortKey="Haslinger, Bernhard" sort="Haslinger, Bernhard" uniqKey="Haslinger B" first="Bernhard" last="Haslinger">Bernhard Haslinger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24944</idno><idno type="RBID">pubmed:22328061</idno><idno type="pmid">22328061</idno><idno type="wicri:Area/PubMed/Corpus">000E63</idno><idno type="wicri:Area/PubMed/Curation">000E63</idno><idno type="wicri:Area/PubMed/Checkpoint">000F29</idno><idno type="wicri:Area/Ncbi/Merge">003567</idno><idno type="wicri:Area/Ncbi/Curation">003567</idno><idno 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Haute-Bavière</region></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Dresel, Christian" sort="Dresel, Christian" uniqKey="Dresel C" first="Christian" last="Dresel">Christian Dresel</name></author><author><name sortKey="Hennenlotter, Andreas" sort="Hennenlotter, Andreas" uniqKey="Hennenlotter A" first="Andreas" last="Hennenlotter">Andreas Hennenlotter</name></author><author><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name></author><author><name sortKey="Haslinger, Bernhard" sort="Haslinger, Bernhard" uniqKey="Haslinger B" first="Bernhard" last="Haslinger">Bernhard Haslinger</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" 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xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Basal Ganglia</term><term>Motor Cortex</term><term>Neural Pathways</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term><term>Imagination</term><term>Movement</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Dystonic Disorders</term><term>Motor Cortex</term><term>Neural Pathways</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Photic Stimulation</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathophysiology of idiopathic focal hand dystonia (writer's cramp) is characterized by deficient inhibitory basal ganglia function and altered cortical sensorimotor processing. To explore if this is already a primary finding in dystonia for internal movement simulation independent of dystonic motor output or abnormal sensory input, we investigated the neural correlates of movement imagination and observation in patients with writer's cramp. Event-related fMRI was applied during kinesthetic motor imagery of drawing simple geometric figures (imagination task) and passively observing videos of hands drawing identical figures (observation task). Compared with healthy controls, patients with writer's cramp showed deficient activation of the left primary sensorimotor cortex, mesial and left dorsal premotor cortex, bilateral putamen, and bilateral thalamus during motor imagery. No significant signal differences between both groups were found during the observation task. We conclude that internal movement simulation and planning as tested during imagination of hand movements appear to be dysfunctional in patients with writer's cramp, whereas visual signal processing and observation-induced activation are unaffected. Deficient basal ganglia-premotor activation could be a correlate of impaired basal ganglia inhibition and focusing during the selection of motor programs in dystonia. This finding seems to be an intrinsic deficit, as it is found during motor imagery in the absence of dystonic symptoms.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université technique de Munich</li></orgName></list><tree><noCountry><name sortKey="Dresel, Christian" sort="Dresel, Christian" uniqKey="Dresel C" first="Christian" last="Dresel">Christian Dresel</name><name sortKey="Haslinger, Bernhard" sort="Haslinger, Bernhard" uniqKey="Haslinger B" first="Bernhard" last="Haslinger">Bernhard Haslinger</name><name sortKey="Hennenlotter, Andreas" sort="Hennenlotter, Andreas" uniqKey="Hennenlotter A" first="Andreas" last="Hennenlotter">Andreas Hennenlotter</name><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Castrop, Florian" sort="Castrop, Florian" uniqKey="Castrop F" first="Florian" last="Castrop">Florian Castrop</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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